The Monro-Kellie Doctrine: A Review and Call for Revision Abstract SUMMARY: The Monro-Kellie doctrine is a well-accepted principle of intracranial hemodynamics. It has undergone few consequential revisions since it was established. Its principle is straightforward: The combined volume of neuronal tissue, blood, and CSF is constant. To maintain homeostatic intracranial pressure, any increase or decrease in […]
Stroke and Emerging Blood Biomarkers: A Clinical Prospective Abstract Stroke constitutes the primary source of adult functional disability, exhibiting a paramount socioeconomic burden. Thus, it is of great importance that the prediction of stroke outcome be both prompt and accurate. Although modern neuroimaging and neurophysiological techniques are accessible, easily available blood biomarkers reflecting underlying stroke-related […]
Treatments in Ischemic Stroke: Current and Future Abstract Background and Aim: Despite progress made over the last 30 years, stroke is still a leading cause of disability and mortality; likewise, its burden is expected to increase over the next decades, due to population growth and aging. The development of drugs with better safety-efficacy profiles as well […]
2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association Antecedentes y objetivo La hemorragia intracerebral (ICH) continúa siendo una forma mortal de accidente cerebrovascular; La mortalidad a los 90 días oscila entre el 15 % y el 40 %. Debido al aumento de la edad […]
Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence Abstract Background Convulsive status epilepticus is the most severe form of epilepsy and requires urgent treatment. We synthesised the current evidence on first-line treatments for controlling seizures in adults with convulsive status epilepticus before, or at, arrival […]
Management of traumatic brain injury: a narrative review of current evidence Summary Globally, approximately 70 million people sustain traumatic brain injury each year and this can have significant physical, psychosocial and economic consequences for patients, their families and society. The aim of this review is to provide clinicians with a summary of recent studies of […]
Management of status epilepticus: a narrative review SummaryStatus epilepticus causes prolonged or repetitive seizures that, if left untreated, can lead to neuronal injury, severe disability, coma and death in paediatric and adult populations. While convulsive status epilepticus can be diagnosed using clinical features alone, non-convulsive status epilepticus requires confirmation by electroencephalogram. Early seizure control remains […]
Imaging Acute Stroke: From One-Size-Fit-All to Biomarkers Abstract In acute stroke management, time window has been rigidly used as a guide for decades and the reperfusion treatment is only available in the first few limited hours. Recently, imaging-based selection of patients has successfully expanded the treatment window out to 16 and even 24 h in […]
Highlights Both lower and higher levels of BUN were associated with excess risks of total and ischemic stroke independent of eGFR. Extreme BUN levels, even within the clinically normal range, may confer potential risks of stroke previously unidentified. A U-shaped relationship was identified between BUN/Cr and total stroke and its subtypes. Abstract Background and aims […]
Introducción Los desórdenes funcionales son afecciones que se originan primariamente por un trastorno del funcionamiento del sistema nervioso más que de una enfermedad fisiopatológica claramente identificable. Ejemplos de éstos son el síndrome de intestino irritable, la fibromialgia y el trastorno neurológico funcional. En este artículo, los autores realizaron una búsqueda bibliográfica de revisiones sistemáticas […]