The relation of 12 lead ECG to the cardiac anatomy: The normal CineECG

The relation of 12 lead ECG to the cardiac anatomy: The normal CineECG Background The interpretation of the 12‑lead ECG is notoriously difficult and requires experts to distinguish normal from abnormal ECG waveforms. ECG waveforms depend on body build and electrode positions, both often different in males and females. To relate the ECG waveforms to cardiac anatomical […]

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Systemic lupus erythematosus: a clinical update

Systemic lupus erythematosus: a clinical update Abstract Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease known for its complexity and heterogeneity. Striking diversity can be observed between individual patients, in terms of clinical manifestations, serological abnormalities, disease progression and response to therapy. Furthermore, dysfunction of a broad range of immune pathways underlies disease development […]

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Blood urea nitrogen, blood urea nitrogen to creatinine ratio and incident stroke: The Dongfeng-Tongji cohort

Highlights Both lower and higher levels of BUN were associated with excess risks of total and ischemic stroke independent of eGFR. Extreme BUN levels, even within the clinically normal range, may confer potential risks of stroke previously unidentified. A U-shaped relationship was identified between BUN/Cr and total stroke and its subtypes. Abstract Background and aims […]

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Imaging of Coronavirus Disease 2019 Infection From Head to Toe: A Primer for the Radiologist

Abstract Coronavirus Disease 2019 (COVID-19) disease has rapidly spread around the world after initial identification in Wuhan, China, in December 2019. Most common presentation is mild or asymptomatic disease, followed by pneumonia, and rarely- multiorgan failure and Acute Respiratory Distress Syndrome (ARDS). Knowledge about the pathophysiology, imaging and treatment of this novel virus is rapidly evolving due to ongoing worldwide research. Most […]

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Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature

Abstract Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely available drugs with anti‐inflammatory and analgesic properties. Their mechanism of action is associated with the enzymes of the arachidonic acid cycle (cyclooxygenases: COX‐1 and COX‐2). The cyclooxygenase pathway results in the formation of prostanoids (prostaglandins [PGs], prostacyclins, and thromboxanes). It affects various structures of the human body, including […]

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Portal Hypertension and Ascites: Patient-and Population-centered Clinical Practice Guidelines by the Italian Association for the Study of the Liver (AISF)

Abstract Portal hypertension and ascites are two crucial events in the natural history of liver cirrhosis, whose appearance marks a downward shift in the prognosis of the disease. Over the years, several international and national societies have issued clinical practice guidelines for the diagnosis and management of portal hypertension and ascites. The present document addresses […]

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2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.

The aim of this ESC Guideline is to help health professionals manage people with heart failure (HF) according to the best available evidence. Fortunately, we now have a wealth of clinical trials to help us select the best management to improve the outcomes for people with HF; for many, it is now both preventable and […]

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Severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A prospective French multicenter cohort

Background A small proportion of patients with chronic obstructive pulmonary disease (COPD) patients present severe pulmonary hypertension (PH), defined by mean pulmonary artery pressure (mPAP) ≥35 mm Hg measured by right heart catheterization. Little is known about the characteristics of severe PH-COPD. The aim of the study based on a national registry was to describe […]

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The furosemide stress test: current use and future potential

Abstract Loop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preventing or treating pulmonary edema. The naturetic response to […]

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Una Perspectiva Futura de la Historia Clínica

¿Cuánto tiempo le dedicamos a realizar una historia clínica? ¿Cuánto tiempo le dedicamos a nuestros pacientes? ¿Qué especialidad le dedica más tiempo a realizar una historia clínica? ¿Cuál es la perspectiva de nuestros pacientes? ¿Inteligencia artificial vs razonamiento clínico humano?  ¿iPatients?  Descubre las respuestas a todas estas preguntas…  

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