Investigación

Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm

Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm Abstract Background Patients with end-stage renal disease (ESRD) often present with an increased risk of cardiovascular disease. Conditions of compromised cardiovascular health such as atrial fibrillation (AFIB) and peripheral arterial disease (PAD) may alter biomarker levels in a way that reflects worsening ESRD. This study […]

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Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Italian Society of Diabetology (SID) and the Italian Society of Obesity (SIO)

Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Italian Society of Diabetology (SID) and the Italian Society of Obesity (SIO) Abstract Nonalcoholic fatty liver disease (NAFLD) is a common and emerging liver disease in adults, paralleling the epidemic of obesity […]

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Potential effects and application prospect of angiotensin receptor-neprilysin inhibitor in diabetic kidney disease

Potential effects and application prospect of angiotensin receptor-neprilysin inhibitor in diabetic kidney disease Highlights • ARNI promotes natriuresis and reduces blood pressure, contributing to renoprotection in diabetic patients. • ARNI is promising for ameliorating inflammation, oxidative stress, renal dysfunction and histopathologic changes of kidney. • ARNI may improve insulin resistance and blood glucose regulation via […]

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Recategorization of Non-Aspirin Nonsteroidal Anti-inflammatory Drugs According to Clinical Relevance: Abandoning the Traditional NSAID Terminology

Recategorization of Non-Aspirin Nonsteroidal Anti-inflammatory Drugs According to Clinical Relevance: Abandoning the Traditional NSAID Terminology Abstract Non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, fever, and inflammation. Historically, NSAIDs have been categorized as traditional NSAIDs and newer cyclooxygenase (COX)-2 inhibitors (coxibs). However, traditional NSAIDs also inhibit the COX-1 and COX-2 enzyme isoforms […]

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Unexplained hemorrhagic syndrome? Consider acquired hemophilia A or B

Unexplained hemorrhagic syndrome? Consider acquired hemophilia A or B Abstract There is a dire need to develop an algorithm to improve the recognition of acquired hemophilia A and B (AHA and AHB) in clinical practice. Initial and intensive care unit (ICU) management of the disorder is particular and represents a challenge for the internist/hematologist and […]

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2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway

2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway Las pautas de práctica son recomendaciones desarrolladas sistemáticamente que ayudan al médico y al paciente a tomar decisiones sobre la atención médica. Estas recomendaciones pueden adoptarse, modificarse o rechazarse de acuerdo con las necesidades y limitaciones clínicas y no pretenden reemplazar las políticas […]

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2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain El dolor de pecho es una de las razones más comunes por las que las personas buscan atención médica. Esta guía se desarrolló para la evaluación del dolor torácico agudo o estable en entornos ambulatorios y de urgencias, haciendo hincapié en el diagnóstico de dolor […]

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The diagnosis of asthma. Can physiological tests of small airways function help?

The diagnosis of asthma. Can physiological tests of small airways function help? Abstract Asthma is a common, chronic, and heterogeneous disease with a global impact and substantial economic costs. It is also associated with significant mortality and morbidity and the burden of undiagnosed asthma is significant. Asthma can be difficult to diagnose as there is […]

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Non-resuscitation fluid in excess of hydration requirements is associated with higher mortality in critically ill children

Non-resuscitation fluid in excess of hydration requirements is associated with higher mortality in critically ill children Abstract Background Large volumes of non-resuscitation fluids are often administered to critically ill children. We hypothesize that excess maintenance fluid is a significant contributor to non-resuscitation fluid and that non-resuscitation fluid administered beyond hydration requirements is associated with worse […]

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Antibiotics in the pipeline: a literature review (2017–2020)

Antibiotics in the pipeline: a literature review (2017–2020) Abstract Introduction Antimicrobial resistance (AMR) is an emerging global threat. It increases mortality and morbidity and strains healthcare systems. Health care professionals can counter the rising AMR by promoting antibiotic stewardship and facilitating new drug development. Even with the economic and scientific challenges, it is reassuring that […]

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