The Monro-Kellie Doctrine: A Review and Call for Revision Abstract SUMMARY: The Monro-Kellie doctrine is a well-accepted principle of intracranial hemodynamics. It has undergone few consequential revisions since it was established. Its principle is straightforward: The combined volume of neuronal tissue, blood, and CSF is constant. To maintain homeostatic intracranial pressure, any increase or decrease in […]
Obstetric management of the most common autoimmune diseases: A narrative review Abstract Historically, women with an autoimmune disease (AD) could not get pregnant due to infertility frequently linked to the medical condition or because the pregnancy was contraindicated, as it could harm the mother and the future child. Sometimes, pregnancy was contraindicated because the medication […]
Treatments in Ischemic Stroke: Current and Future Abstract Background and Aim: Despite progress made over the last 30 years, stroke is still a leading cause of disability and mortality; likewise, its burden is expected to increase over the next decades, due to population growth and aging. The development of drugs with better safety-efficacy profiles as well […]
Pharmacotherapy to delay the progression of diabetic kidney disease in people with type 2 diabetes: past, present and future Abstract Diabetic kidney disease (DKD) is a leading cause of morbidity and mortality among people living with diabetes, and is one of the most important causes of end stage renal disease worldwide. In order to reduce […]
Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm Abstract Background Patients with end-stage renal disease (ESRD) often present with an increased risk of cardiovascular disease. Conditions of compromised cardiovascular health such as atrial fibrillation (AFIB) and peripheral arterial disease (PAD) may alter biomarker levels in a way that reflects worsening ESRD. This study […]
Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Italian Society of Diabetology (SID) and the Italian Society of Obesity (SIO) Abstract Nonalcoholic fatty liver disease (NAFLD) is a common and emerging liver disease in adults, paralleling the epidemic of obesity […]
Potential effects and application prospect of angiotensin receptor-neprilysin inhibitor in diabetic kidney disease Highlights • ARNI promotes natriuresis and reduces blood pressure, contributing to renoprotection in diabetic patients. • ARNI is promising for ameliorating inflammation, oxidative stress, renal dysfunction and histopathologic changes of kidney. • ARNI may improve insulin resistance and blood glucose regulation via […]
Recategorization of Non-Aspirin Nonsteroidal Anti-inflammatory Drugs According to Clinical Relevance: Abandoning the Traditional NSAID Terminology Abstract Non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, fever, and inflammation. Historically, NSAIDs have been categorized as traditional NSAIDs and newer cyclooxygenase (COX)-2 inhibitors (coxibs). However, traditional NSAIDs also inhibit the COX-1 and COX-2 enzyme isoforms […]
Unexplained hemorrhagic syndrome? Consider acquired hemophilia A or B Abstract There is a dire need to develop an algorithm to improve the recognition of acquired hemophilia A and B (AHA and AHB) in clinical practice. Initial and intensive care unit (ICU) management of the disorder is particular and represents a challenge for the internist/hematologist and […]
2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway Las pautas de práctica son recomendaciones desarrolladas sistemáticamente que ayudan al médico y al paciente a tomar decisiones sobre la atención médica. Estas recomendaciones pueden adoptarse, modificarse o rechazarse de acuerdo con las necesidades y limitaciones clínicas y no pretenden reemplazar las políticas […]