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EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis Introduction Patients with cirrhosis frequently acquire substantial alterations in their haemostatic system that are apparent during screening with basic tests of haemostasis (mainly international normalised ratio [INR], activated partial thromboplastin time [APTT] and platelet count). Historically, these changes were […]

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Pharmacotherapy to delay the progression of diabetic kidney disease in people with type 2 diabetes: past, present and future

Pharmacotherapy to delay the progression of diabetic kidney disease in people with type 2 diabetes: past, present and future Abstract Diabetic kidney disease (DKD) is a leading cause of morbidity and mortality among people living with diabetes, and is one of the most important causes of end stage renal disease worldwide. In order to reduce […]

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Management of hypertensive emergencies: a practical approach

Management of hypertensive emergencies: a practical approach Abstract Background: Acute increases of high blood pressure values, usually described as ‘hypertensive crises’, ‘hypertensive urgencies’ or ‘hypertensive emergencies’, are common causes of patients’ presentation to emergency departments. Owing to the lack of ad hoc randomized clinical trials, current recommendations/suggestions for treatment of these patients are not evidenced-based and, […]

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Hyperosmolar hyperglycaemic state management guidelines updated (The Joint British Diabetes Societies for Inpatient Care)

Hyperosmolar hyperglycaemic state management guidelines updated Se han publicado los últimos consejos sobre cómo manejar el estado hiperglucémico hiperosmolar en adultos con diabetes. Las Sociedades Británicas Conjuntas de Diabetes para la Atención de Pacientes Hospitalizados (JBDS-IP) han publicado una guía revisada, El manejo del estado hiperglucémico hiperosmolar en adultos  , para mejorar la forma en que se […]

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SGLT-2 inhibitors for treatment of heart failure in patients with and without type 2 diabetes: A practical approach for routine clinical practice

SGLT-2 inhibitors for treatment of heart failure in patients with and without type 2 diabetes: A practical approach for routine clinical practice Highlights SGLT-2i are a promising class of agents for heart failure and chronic kidney disease. An algorithm is provided for prescribing SGLT-2i using a multidisciplinary approach. Tips to prevent common adverse effects with […]

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Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence

Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence Abstract Background Convulsive status epilepticus is the most severe form of epilepsy and requires urgent treatment. We synthesised the current evidence on first-line treatments for controlling seizures in adults with convulsive status epilepticus before, or at, arrival […]

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Management of traumatic brain injury: a narrative review of current evidence

Management of traumatic brain injury: a narrative review of current evidence Summary Globally, approximately 70 million people sustain traumatic brain injury each year and this can have significant physical, psychosocial and economic consequences for patients, their families and society. The aim of this review is to provide clinicians with a summary of recent studies of […]

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Management of status epilepticus: a narrative review

Management of status epilepticus: a narrative review SummaryStatus epilepticus causes prolonged or repetitive seizures that, if left untreated, can lead to neuronal injury, severe disability, coma and death in paediatric and adult populations. While convulsive status epilepticus can be diagnosed using clinical features alone, non-convulsive status epilepticus requires confirmation by electroencephalogram. Early seizure control remains […]

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WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections Abstract Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. Together, the World Society of Emergency Surgery, the Global Alliance for […]

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Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm

Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm Abstract Background Patients with end-stage renal disease (ESRD) often present with an increased risk of cardiovascular disease. Conditions of compromised cardiovascular health such as atrial fibrillation (AFIB) and peripheral arterial disease (PAD) may alter biomarker levels in a way that reflects worsening ESRD. This study […]

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