Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial

Background The IL-33/ST2 pathway is linked with asthma susceptibility. Inhaled allergens, pollutants, and respiratory viruses, which trigger asthma exacerbations, induce release of IL-33, an epithelial-derived “alarmin.” Astegolimab, a human IgG2 mAb, selectively inhibits the IL-33 receptor, ST2. Approved biologic therapies for severe asthma mainly benefit patients with elevated blood eosinophils (type 2-high), but limited options are […]

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Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature

Abstract Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely available drugs with anti‐inflammatory and analgesic properties. Their mechanism of action is associated with the enzymes of the arachidonic acid cycle (cyclooxygenases: COX‐1 and COX‐2). The cyclooxygenase pathway results in the formation of prostanoids (prostaglandins [PGs], prostacyclins, and thromboxanes). It affects various structures of the human body, including […]

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Portal Hypertension and Ascites: Patient-and Population-centered Clinical Practice Guidelines by the Italian Association for the Study of the Liver (AISF)

Abstract Portal hypertension and ascites are two crucial events in the natural history of liver cirrhosis, whose appearance marks a downward shift in the prognosis of the disease. Over the years, several international and national societies have issued clinical practice guidelines for the diagnosis and management of portal hypertension and ascites. The present document addresses […]

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2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.

The aim of this ESC Guideline is to help health professionals manage people with heart failure (HF) according to the best available evidence. Fortunately, we now have a wealth of clinical trials to help us select the best management to improve the outcomes for people with HF; for many, it is now both preventable and […]

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Severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A prospective French multicenter cohort

Background A small proportion of patients with chronic obstructive pulmonary disease (COPD) patients present severe pulmonary hypertension (PH), defined by mean pulmonary artery pressure (mPAP) ≥35 mm Hg measured by right heart catheterization. Little is known about the characteristics of severe PH-COPD. The aim of the study based on a national registry was to describe […]

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The furosemide stress test: current use and future potential

Abstract Loop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preventing or treating pulmonary edema. The naturetic response to […]

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Una Perspectiva Futura de la Historia Clínica

¿Cuánto tiempo le dedicamos a realizar una historia clínica? ¿Cuánto tiempo le dedicamos a nuestros pacientes? ¿Qué especialidad le dedica más tiempo a realizar una historia clínica? ¿Cuál es la perspectiva de nuestros pacientes? ¿Inteligencia artificial vs razonamiento clínico humano?  ¿iPatients?  Descubre las respuestas a todas estas preguntas…   Related Posts:Veinte errores comunes en la […]

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A case of adrenal Cushing’s syndrome and primary hyperparathyroidism due to an atypical parathyroid adenoma

Abstract Cushing’s syndrome is a rare disorder of cortisol excess and is associated with significant morbidity and mortality. Hypercalcaemia due to hyperparathyroidism is a common condition; however, in 10% of young patients, it is associated with other endocrinopathies and occurs due to a genetic variant [e.g. multiple endocrine neoplasia (MEN) type 1 (MEN1), MEN2 or […]

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Diarrea Crónica

 Resumen La diarrea crónica es común y se presenta como la primera manifestación de varios diagnósticos o como un trastorno prolongado en el que la frecuencia, la urgencia y la incontinencia de las deposiciones tienen un impacto importante en la calidad de vida. Es necesario realizar una buena historia clínica, con diferentes causas a considerar: […]

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CONVOCATORIA A POSGRADOS DE MEDICINA 2021-2022 CMM MSPAS IGSS

CONVOCATORIA A POSGRADOS DE MEDICINA 2021-2022 La Facultad de Ciencias Médicas y de la Salud, en colaboración con el Ministerio de Salud Pública y Asistencia Social (MSPAS), Centro Médico Militar (CMM) y el Instituto Guatemalteco de Seguridad Social (IGGS) invita a participar en la convocatoria de Posgrados 2021. Puede consultar las bases y toda la información en: Convocatoria Posgrado CMM […]

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